The Dual Glucagon-Like Peptide-1 (GLP-1)/Glucagon Receptor Agonist MEDI0382 Improves Metabolic and Hepatic Indices of NASH in Mice

Trevaskis James; Beaton Michelle L.; Bednarek Maria; Hornigold David C.; Naylor Jacqui; Collinson Andie; Veidal Sanne Skovgaard; Madsen Andreas Nygaard; Ambery Philip; Henderson Simon; Coghlan Matthew P.; Grimsby Joseph; Rhodes Christopher; Jermutus Lutz; Konkar Anish

首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >The Dual Glucagon-Like Peptide-1 (GLP-1)/Glucagon Receptor Agonist MEDI0382 Improves Metabolic and Hepatic Indices of NASH in Mice

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The Dual Glucagon-Like Peptide-1 (GLP-1)/Glucagon Receptor Agonist MEDI0382 Improves Metabolic and Hepatic Indices of NASH in Mice

机译：双胰高血糖素样肽-1（GLP-1）/胰高血糖素受体Agonist Medi0382改善了小鼠中的纳什的代谢和肝脏指数

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来源
《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2016年第s1期|共1页
作者
Trevaskis James; Beaton Michelle L.; Bednarek Maria; Hornigold David C.; Naylor Jacqui; Collinson Andie; Veidal Sanne Skovgaard; Madsen Andreas Nygaard; Ambery Philip; Henderson Simon; Coghlan Matthew P.; Grimsby Joseph; Rhodes Christopher; Jermutus Lutz; Konkar Anish;
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MedImmune LLC Gaithersburg MD USA;

MedImmune LLC Gaithersburg MD USA;

MedImmune LTD Cambridge England;

MedImmune LTD Cambridge England;

MedImmune LTD Cambridge England;

MedImmune LTD Cambridge England;

Gubra Copenhagen Denmark;

Gubra Copenhagen Denmark;

MedImmune LTD Cambridge England;

MedImmune LTD Cambridge England;

MedImmune LTD Cambridge England;

MedImmune LLC Gaithersburg MD USA;

MedImmune LLC Gaithersburg MD USA;

MedImmune LTD Cambridge England;

MedImmune LLC Gaithersburg MD USA;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
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1. The Dual Glucagon-Like Peptide-1 (GLP-1)/Glucagon Receptor Agonist MEDI0382 Improves Metabolic and Hepatic Indices of NASH in Mice [J] . Trevaskis James, Beaton Michelle L., Bednarek Maria, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第S1期

机译：双胰高血糖素样肽-1（GLP-1）/胰高血糖素受体Agonist Medi0382改善了小鼠中的纳什的代谢和肝脏指数
2. MEDI0382, a dual GLP-1/glucagon receptor agonist, exerts beneficial effects on mitochondrial content and function in primary hepatocytes from lean and NASH mice [J] . Beaton Michelle L., Grimsby Joseph, Rhodes Christopher, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第S1期

机译：双GLP-1 / Glucagon受体激动剂MEDI0382对来自瘦和腹部小鼠的主要肝细胞的线粒体含量和功能施加有益作用
3. Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice [J] . American Journal of Physiology . 2012,第4aPta1期

机译：胰高血糖素样肽1受体激动剂可改善小鼠非酒精性脂肪性肝炎的代谢，生化和组织病理学指标
4. Quantitation of Glucagon-like peptide-1, GLP-1 (7-36) amide, and the DPP4-catalyzed degradation product GLP-1 (9-36) amide by LC/MS [C] . Rong-Sheng Yang, Yan-Hui Liu, Aileen Soriano, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：通过LC / MS定量胰高血糖素肽-1，GLP-1（7-36）酰胺和DPP4催化的降解产物GLP-1（9-36）酰胺
5. Backbone modification of glucagon-like peptide-1 (GLP-1) to alter signaling at the GLP-1 receptor. [D] . Hager, Marlies Veronica. 2017

机译：胰高血糖素样肽1（GLP-1）的骨干修饰，以改变GLP-1受体处的信号传导。
6. A Novel Glucagon-like Peptide-1 (GLP-1)/Glucagon Hybrid Peptide with Triple-acting Agonist Activity at Glucose-dependent Insulinotropic Polypeptide GLP-1 and Glucagon Receptors and Therapeutic Potential in High Fat-fed Mice [O] . Victor A. Gault, Vikas K. Bhat, Nigel Irwin, 2013

机译：一种新型的胰高血糖素样肽-1（GLP-1）/胰高血糖素杂合肽在依赖葡萄糖的促胰岛素多肽GLP-1和胰高血糖素受体上具有三作用激动剂活性并且在高脂喂养小鼠中具有治疗潜力
7. Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists. [O] . Daniel J Cuthbertson, Andrew Irwin, Chris J Gardner, 2012

机译：改善的血糖与肥胖，2型糖尿病，给予胰高血糖素样肽-1（GLp-1）受体激动剂的患者的肝脏脂肪减少相关。

The Dual Glucagon-Like Peptide-1 (GLP-1)/Glucagon Receptor Agonist MEDI0382 Improves Metabolic and Hepatic Indices of NASH in Mice

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