Preclinical characterization of GNS561 a novel first in class autophagy inhibitor able to kill hepatocellular carcinoma cancer stem cell

Halfon Philippe; Bassissi Firas; Brun Sonia; Gifu Elena-Patricia; Courcambeck Jerome; Merle Philippe; De Fromentel Claude

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Preclinical characterization of GNS561 a novel first in class autophagy inhibitor able to kill hepatocellular carcinoma cancer stem cell

机译：GNS561临床表征GNS561一种新型在类自噬抑制剂中首先能够杀死肝细胞癌癌症干细胞

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来源
《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2016年第s1期|共1页
作者
Halfon Philippe; Bassissi Firas; Brun Sonia; Gifu Elena-Patricia; Courcambeck Jerome; Merle Philippe; De Fromentel Claude;
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作者单位

Genosci Pharma Marseille France;

Genosci Pharma Marseille France;

Genosci Pharma Marseille France;

Univ Lyon 1 CNRS 5286 INSERM CRCL U1052 Ctr Leon Berard Hosp Civils Lyon Lyon France;

Genosci Pharma Marseille France;

Univ Lyon 1 CNRS 5286 INSERM CRCL U1052 Ctr Leon Berard Hosp Civils Lyon Lyon France;

Univ Lyon 1 CNRS 5286 INSERM CRCL U1052 Ctr Leon Berard Hosp Civils Lyon Lyon France;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
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1. Preclinical characterization of GNS561 a novel first in class autophagy inhibitor able to kill hepatocellular carcinoma cancer stem cell [J] . Halfon Philippe, Bassissi Firas, Brun Sonia, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第S1期

机译：GNS561临床表征GNS561一种新型在类自噬抑制剂中首先能够杀死肝细胞癌癌症干细胞
2. Characterization and Validation of Hepatocellular Carcinoma (HCC) Xenograft tumor as a Suitable Liver Cancer Model for Preclinical Mesenchymal Stem Cell Studies [J] . Saieh Hajighasemlou, Saeedreza Pakzad, Jafar Ai, Asian Pacific Journal of Cancer Prevention . 2018,第6期

机译：肝细胞癌（HCC）异种移植肿瘤的表征和验证，作为临床前间充质干细胞研究的合适肝癌模型
3. SSPH I, a Novel Anti-Cancer Saponin, Inhibits Autophagy and Induces Apoptosis via ROS Accumulation and ERK1/2 Signaling Pathway in Hepatocellular Carcinoma Cells [J] . Jin-ling Zhou, Xiu-ying Huang, Han-chen Qiu, OncoTargets and therapy . 2020,第2期

机译：SSPH I，一种新型抗癌皂苷，抑制肝细胞癌细胞中的ROS累积和ERK1 / 2信号通路诱导凋亡并诱导细胞凋亡
4. Phenolic Phytochemicals Derived from Red Pine (Pinus densiflora) Inhibit the Invasion and Migration of SK-Hep-1 Human Hepatocellular Carcinoma Cells [C] . SANG JUN LEE, KI WON LEE, HAENG JEON HUR, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：赤松（Pinus densiflora）衍生的酚类植物化学物质抑制SK-Hep-1人肝癌细胞的侵袭和迁移
5. The anti-cancer activities of Paeoniae Radix extracts on human hepatocellular carcinoma cell-line HepG2 and multidrug resistant human hepatocellular carcinoma cell-line R-HepG2 and their action mechanisms. [D] . Li, Lok Yee Mandy. 2004

机译：e药提取物对人肝癌细胞HepG2和多药耐药人肝癌细胞R-HepG2的抗癌活性及其作用机制。
6. Blocking CDK1/PDK1/β-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma [O] . Chuan Xing Wu, Xiao Qi Wang, Siu Ho Chok, 2018

机译：在肝细胞癌的临床前模型中通过靶向CDK1抑制剂RO3306阻断CDK1 / PDK1 /β-Catenin信号传导可提高靶向索拉非尼治疗索拉非尼的疗效
7. GNS561, a New Autophagy Inhibitor Active against Cancer Stem Cells in Hepatocellular Carcinoma and Hepatic Metastasis from Colorectal Cancer [O] . Sonia Brun, Jean-Marc Pascussi, Elena Patricia Gifu, 2020

机译：GNS561，一种新的自噬抑制剂，其针对肝细胞癌中的癌症干细胞和来自结肠直肠癌的肝脏转移

Preclinical characterization of GNS561 a novel first in class autophagy inhibitor able to kill hepatocellular carcinoma cancer stem cell

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