Evaluation of anti-asthmatic activity of Glycyrrhiza glabra.

摘要

Asthma is a chronic disease associated with allergic reaction in the body. The allergic reaction is due to the production of histamine secreted by the mast cells of the human body. Glycyrrhiza glabra Linn. is a plant of family Fabaceae. The rhizome, stem and seeds of the plant are used as anti-inflammatory drug in the tribal areas. In this research, the crude extract was obtained from the parts of Glycyrrhiza glabra by the process of cold percolation and Soxhlet method. It's different fractions were purified by column chromatography and thin layer chromatography. The purified samples were identified by spectral analysis including HNMR, CNMR and Mass spectroscopy. The swiss variety of albino rats were induced asthma by triple antigen. Purified saponin fraction of the extract of Glycyrrhiza glabra was injected to the infected rats. The result obtained shows that the saponin fraction is effective in triple antigen sensitized albino rats as anti-asthmatic agent. The inhibition on mast cell degranulation took place up to 62% at 25 mg/Kg body weight.