Cyclophosphamide: a novel treatment of gastric antral vascular ectasia associated with systemic sclerosis?

摘要

Systemic sclerosis (SSc) is associated with widespread microangiopathy. Prominent clinical manifestations include nailfold capillary alterations, obliterative small vessel vascular changes in the pulmonary, renal, and myocardial circulations, and cutaneous telangiectasia [1]. The pathogenesis of vascular damage in SSc is poorly understood, effective treatments are lacking, and the process is associated with tremendous morbidity and mortality.