EFFICACY OF ANTI-NAUSEA PREGNANCY DRUG QUESTIONED

摘要

In some countries, doxylamine-pyridoxine is recommended to treat nausea and vomiting during pregnancy; however, evidence for its efficacy comes from a single randomised controlled trial. In PLoS One (17 January 2018), researchers analysed unpublished individual-level data from the trial, including 131 people who received 2-14 doses of doxylamine-pyridoxine 10mg for 14 days, and 125 people assigned to placebo. At the end of the trial, there were missing data on 30 and 39 of these participants, respectively.