Synthetic opioids, such as fentanyl, were implicated in more overdose-related deaths in 2016 than prescription opioids in the United States. Of 42,249 opioid-related deaths in 2016,19,413 (45.9%) involved synthetic opioids, compared with 3,007 deaths in 2010. A total of 17,087 opioid-related deaths (40.4%) involved prescription opioids and a further 15,469 deaths (36.6%) involved heroin in 2016.
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