Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial

Kandzari David E.; Boehm Michael; Mahfoud Felix; Townsend Raymond R.; Weber Michael A.; Pocock Stuart; Tsioufis Konstantinos; Tousoulis Dimitrios; Choi James W.; East Cara; Brar Sandeep; Cohen Sidney A.; Fahy Martin; Pilcher Garrett; Kario Kazuomi

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Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial

机译：肾脏消除对抗高血压药物存在血压的影响：6个月的疗效和安全结果来自SPERAL-on PERE概念随机试验

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Background Previous catheter-based renal denervation studies have reported variable efficacy results. We aimed to evaluate safety and blood pressure response after renal denervation or sham control in patients with uncontrolled hypertension on antihypertensive medications with drug adherence testing.

机译：背景技术以前的基于导管的肾脏消除性研究已经报道了可变疗效结果。我们的旨在评估肾脏去除剂或假手术患者患者的安全性和血压反应，对药物粘附试验的抗高血压药物的抗高血压药物。

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《The Lancet》 |2018年第10137期|共10页
作者
Kandzari David E.; Boehm Michael; Mahfoud Felix; Townsend Raymond R.; Weber Michael A.; Pocock Stuart; Tsioufis Konstantinos; Tousoulis Dimitrios; Choi James W.; East Cara; Brar Sandeep; Cohen Sidney A.; Fahy Martin; Pilcher Garrett; Kario Kazuomi;
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作者单位

Piedmont Heart Inst Dept Intervent Cardiol Atlanta GA USA;

Univ Saarland Univ Klinikum Saarlandes Dept Internal Med Homburg Germany;

Univ Saarland Univ Klinikum Saarlandes Dept Internal Med Homburg Germany;

Univ Penn Perelman Sch Med Dept Med Philadelphia PA USA;

SUNY Downstate Coll Med Dept Med Brooklyn NY USA;

London Sch Hyg &

Trop Med Dept Med Stat London England;

Univ Athens Hippocrat Hosp Dept Cardiol Athens Greece;

Univ Athens Hippocrat Hosp Dept Cardiol Athens Greece;

Baylor Jack &

Jane Hamilton Heart &

Vasc Hosp Dept Cardiol Dallas TX USA;

Baylor Jack &

Jane Hamilton Heart &

Vasc Hosp Dept Cardiol Dallas TX USA;

Medtron PLC Santa Rosa CA USA;

Univ Penn Perelman Sch Med Dept Med Philadelphia PA USA;

Medtron PLC Santa Rosa CA USA;

Medtron PLC Santa Rosa CA USA;

Jichi Med Univ Sch Med Dept Cardiovasc Med Shimotsuke Tochigi Japan;

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正文语种 eng
中图分类医药、卫生;
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专利

1. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial [J] . Kandzari David E., Boehm Michael, Mahfoud Felix, The Lancet . 2018,第10137期

机译：肾脏消除对抗高血压药物存在血压的影响：6个月的疗效和安全结果来自SPERAL-on PERE概念随机试验
2. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial [J] . Bohm Michael, Kario Kazuomi, Kandzari David E., The Lancet . 2020,第10234期

机译：导管肾去除术治疗抗高血压药物（SPYRAL HTN-OFF MED PECOPOTAL）的疗效：多期，随机，假手术试验
3. Ambulatory heart rate reduction after catheter-based renal denervation in hypertensive patients not receiving anti-hypertensive medications: data from SPYRAL HTN-OFF MED, a randomized, sham-controlled, proof-of-concept trial [J] . Boehm Michael, Mahfoud Felix, Townsend Raymond R., European Heart Journal: The Journal of the European Society of Cardiology . 2019,第9期

机译：高血压患者的导管肾病后的动态心率降低未接受抗高血压药物：来自Spyral HTN-OFF的数据，随机，假控制，概念证明试验
4. Assessment of Mean Arterial Blood Pressure Using Spectral and Chaotic Analyses in Different Antihypertensive Drug Treatments [C] . B. Y. Liau, C. C. Chiu, S. J. Yeh Computers in Cardiology . 2004

机译：不同抗高血压药物治疗中使用光谱和混沌分析评估平均动脉血压
5. Safety Signal Detection for Antihypertensive Drug-Induced Cleft Lip and/or Palate and Evaluation of Risk Perception for Medication Use in Pregnancy Among Mothers With Children With Cleft Lip and/or Palate. [D] . Palaska, Pinelopi-Kleio. 2013

机译：降压药物诱发的唇裂和/或Pal裂的安全性信号检测，以及对有唇裂和/或Pal裂患儿的母亲进行妊娠用药的风险感知评估。
6. Efficacy of self-monitored blood pressure with or without telemonitoring for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial [O] . Richard J McManus, Jonathan Mant, Marloes Franssen, -1

机译：自我监测的血压（有或没有远程监测）对滴定降压药（TASMINH4）的功效：一项未公开的随机对照试验
7. Rationale and design of two randomized sham-controlled trials of catheter-based renal denervation in subjects with uncontrolled hypertension in the absence (SPYRAL HTN-OFF MED Pivotal) and presence (SPYRAL HTN-ON MED Expansion) of antihypertensive medications: a novel approach using Bayesian design [O] . Michael Böhm, Raymond R. Townsend, Kazuomi Kario, 2020

机译：在缺乏控制的高血压术中的两种随机假手术试验的理由与设计缺失的高血压和抗高血压药物的存在（Spyral HTN-on Breating）：一种新的方法贝叶斯设计

Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial

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