Long-term clinical effectiveness of continuous positive airway pressure therapy versus non-invasive ventilation therapy in patients with obesity hypoventilation syndrome: a multicentre, open-label, randomised controlled trial

摘要

Background Obesity hypoventilation syndrome is commonly treated with continuous positive airway pressure or noninvasive ventilation during sleep. Non-invasive ventilation is more complex and costly than continuous positive airway pressure but might be advantageous because it provides ventilatory support. To date there have been no longterm trials comparing these treatment modalities. We therefore aimed to determine the long-term comparative effectiveness of both treatment modalities.