t-BuOK-Mediated Oxidative Dehydrogenative C(sp(3))-H Arylation of 2-Alkylazaarenes with Nitroarenes

摘要

The first transition-metal free and regioselective C(sp(3))-H arylation of 2-alkylazaarenes with nitroarenes has been achieved via t-BuOK-mediated dehydrogenative C(sp(3))-C(sp(2)) coupling. This reaction provides an efficient access to the biologically important and synthetically useful 2-benzyl-substituted azaarenes under mild conditions without the need of prefunctionalization of 2-alkylazaarenes or using the specialized arylating agents.