Gold-Catalyzed Synthesis of 6-Hydroxyindoles from Alkynylcyclohexadienones and Substituted Amines

摘要

An efficient gold-catalyzed formation of 6-hydroxyindoles from substituted alkynylcyclohexadienones and amines have been developed. In this reaction two new C-N bonds were formed, and moderate to very good yields of the 6-hydroxyindole derivatives were obtained in one pot. This organic transformation tolerates a range of substituted alkynylcyclohexadienones and amines, which resulted in 6-hydroxyindole derivatives selectively.