Fe(III)-Catalyzed Decarboxylative C3-Difluoroarylmethylation of Coumarins with alpha,alpha-Difluoroarylacetic Acids

摘要

A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of alpha,alpha-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series of C-3 difluoroarylmethylated coumarins containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.