Pd(II)-Catalyzed Direct gamma-C(sp(3))-H Arylation between Free beta(2)-Amino Esters and beta(3)-Amino Esters and Aryl Iodides Using a Catalytic Transient Directing Group

摘要

Pd(II)-catalyzed direct gamma-C(sp(3))-H arylation coupling with free beta(2)-amino esters and beta(3)-amino esters using a commercially available catalytic transient directing group has been developed. This approach features high efficiency, broad substrate tolerance, easily accessible starting materials, and mild reaction conditions.