Optical techniques for the endoscopic detection of dysplastic colonic lesions

摘要

Most studies reported to date hav^mainiy focused on refining existing prototype instruments or continue on a basic research level, with the ultimate goal of improving sensitivity and specificity for coionic dysplasia, compared with the gold standard of histopathology. It is more than likely that the future diagnostic role of these evolving technologies will involve the combination of two or more complementary technologies, and "molecular targeting" approaches will be crucial for earliest detection. However, despite innovative applications and refinement of the existing ones, large, controlled, prospective multicenter trials are still anxiously awaited by the practicing endoscopist to evaluate the diagnostic role and cost-effectiveness of these emerging technologies in the gastroenterology clinic.