Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial

Bernstein David I.; Wald Anna; Warren Terri; Fife Kenneth; Tyring Stephen; Lee Patricia; Van Wagoner Nick; Magaret Amalia; Flechtner Jessica B.; Tasker Sybil; Chan Jason; Morris Amy; Hetherington Seth

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Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial

机译：用于生殖器疱疹的治疗疫苗单纯疱疹病毒-2感染：随机试验的结果

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Background. Genital herpes simplex virus type 2 (HSV-2) infection causes recurrent lesions and frequent viral shedding. GEN-003 is a candidate therapeutic vaccine containing HSV-2 gD2 Delta TMR and ICP4.2, and Matrix-M2 adjuvant.

机译：背景。生殖器疱疹单纯疱疹病毒2（HSV-2）感染导致复发性病变和频繁的病毒脱落。 GEN-003是含有HSV-2 GD2 DELTA TMR和ICP4.2的候选治疗疫苗，以及基质-M2佐剂。

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来源
《The Journal of Infectious Diseases》 |2017年第6期|共9页
作者
Bernstein David I.; Wald Anna; Warren Terri; Fife Kenneth; Tyring Stephen; Lee Patricia; Van Wagoner Nick; Magaret Amalia; Flechtner Jessica B.; Tasker Sybil; Chan Jason; Morris Amy; Hetherington Seth;
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作者单位

Univ Cincinnati Cincinnati Childrens Hosp Med Ctr Cincinnati OH 45221 USA;

Univ Washington Vaccine &

Fred Hutchinson Canc Res Ctr Seattle WA USA;

Westover Hts Clin Portland OR USA;

Indiana Univ Dept Med Indianapolis IN USA;

Univ Texas Hlth Sci Ctr Houston Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston Houston TX 77030 USA;

Univ Alabama Birmingham Div Infect Dis Birmingham W Midlands England;

Univ Washington Vaccine &

Fred Hutchinson Canc Res Ctr Seattle WA USA;

Genocea Biosci Cambridge MA USA;

Genocea Biosci Cambridge MA USA;

Genocea Biosci Cambridge MA USA;

IND2Results Atlanta GA USA;

Genocea Biosci Cambridge MA USA;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
Genital herpes; herpes simplex virus type 2 infection; therapeutic vaccine; GEN-003; immunotherapy;

机译：生殖器疱疹;单纯疱疹病毒2型感染;治疗疫苗;GEN-003;免疫疗法;

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专利

1. Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial [J] . Bernstein David I., Wald Anna, Warren Terri, The Journal of Infectious Diseases . 2017,第6期

机译：用于生殖器疱疹的治疗疫苗单纯疱疹病毒-2感染：随机试验的结果
2. A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects [J] . de Bruyn G, Vargas-Cortez M, Warren T, Vaccine . 2006,第7期

机译：复制缺陷型（gH缺失）单纯疱疹病毒疫苗治疗免疫功能正常个体生殖器疱疹的随机对照试验
3. Human immunodeficiency virus-1 infection correlates strongly with herpes simplex virus-2 (genital herpes) seropositivity in South African and United States blood donations. [J] . Benjamin RJ, Busch MP, Fang CT, Transfusion: The Journal of the American Association of Blood Banks . 2008,第2期

机译：在南非和美国的献血活动中，人类免疫缺陷病毒1感染与单纯疱疹病毒2（生殖器疱疹）的血清反应呈正相关。
4. Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and "area pudenda" with low-power He-Ne laser or Acyclovir administered orally [C] . Mariano Velez-Gonzalez, Hospital del Mar, Barcelona, Effects of Low-Power Light on Biological Systems . 1996

机译：口服低功率He-Ne激光或阿昔洛韦治疗阴唇和面部单纯疱疹复发，生殖器和单纯性疱疹复发
5. Investigation of herpes simplex virus-2 and Chlamydia trachomatis infections as human papillomavirus cofactors in the etiology of invasive cervical cancer in Brazil and the Philippines. [D] . Smith, Jennifer Susan. 2001

机译：在巴西和菲律宾，浸润性宫颈癌的病因学调查单纯疱疹病毒2型和沙眼衣原体感染作为人乳头瘤病毒辅助因子。
6. Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial [O] . David I. Bernstein, Anna Wald, Terri Warren, -1

机译：生殖器单纯疱疹病毒2感染的治疗性疫苗：随机试验的结果。
7. Dysregulated expression of IFN-γ and IL-10 and impaired IFN-γ-mediated responses at different disease stages in patients with genital herpes simplex virus-2 infection [O] . SINGH, R, KUMAR, A, CREERY, W D, 2003

机译：生殖器单纯疱疹病毒2型感染患者不同疾病阶段IFN-γ和IL-10表达失调及IFN-γ介导的反应减弱

Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial

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