Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study

Stevens Marita; Rusch Sarah; DeVincenzo John; Kim Young-In; Harrison Lisa; Meals Elizabeth A.; Boyers Alison; Fok-Seang Juin; Huntjens Dymphy; Lounis Nacer; Marien Kris; Remmerie Bart; Roymans Dirk; Koul Anil; Verloes Rene

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Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study

机译：口腔JNJ-53718678在健康成人志愿者抗病患者患有呼吸道合胞病毒的健康成人志愿者：安慰剂对照研究

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Background. Respiratory syncytial virus (RSV) disease has no effective treatment. JNJ-53718678 is a fusion inhibitor with selective activity against RSV.

机译：背景。呼吸道合胞病毒（RSV）疾病没有有效的治疗方法。 JNJ-53718678是一种融合抑制剂，具有针对RSV的选择性活性。

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来源
《The Journal of Infectious Diseases》 |2018年第5期|共9页
作者
Stevens Marita; Rusch Sarah; DeVincenzo John; Kim Young-In; Harrison Lisa; Meals Elizabeth A.; Boyers Alison; Fok-Seang Juin; Huntjens Dymphy; Lounis Nacer; Marien Kris; Remmerie Bart; Roymans Dirk; Koul Anil; Verloes Rene;
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作者单位

Janssen Res &

Dev Turnhoutseweg 30 B-2340 Beerse Belgium;

Janssen Res &

Dev Turnhoutseweg 30 B-2340 Beerse Belgium;

Le Bonheur Childrens Hosp Childrens Fdn Res Inst Memphis TN USA;

Le Bonheur Childrens Hosp Childrens Fdn Res Inst Memphis TN USA;

Le Bonheur Childrens Hosp Childrens Fdn Res Inst Memphis TN USA;

Le Bonheur Childrens Hosp Childrens Fdn Res Inst Memphis TN USA;

hVIVO Serv Ltd Queen Mary Bioenterprises Innovat Ctr London England;

hVIVO Serv Ltd Queen Mary Bioenterprises Innovat Ctr London England;

Janssen Res &

Dev Turnhoutseweg 30 B-2340 Beerse Belgium;

Janssen Res &

Dev Turnhoutseweg 30 B-2340 Beerse Belgium;

Janssen Res &

Dev Turnhoutseweg 30 B-2340 Beerse Belgium;

Janssen Res &

Dev Turnhoutseweg 30 B-2340 Beerse Belgium;

Janssen Res &

Dev Turnhoutseweg 30 B-2340 Beerse Belgium;

Janssen Res &

Dev Turnhoutseweg 30 B-2340 Beerse Belgium;

Janssen Res &

Dev Turnhoutseweg 30 B-2340 Beerse Belgium;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
acute lower respiratory tract infection (ALRTI); challenge; respiratory syncytial virus (RSV); RSV fusion inhibitor;

机译：急性下呼吸道感染（ALTI）;挑战;呼吸道合胞病毒（RSV）;RSV融合抑制剂;

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专利

1. Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study [J] . Stevens Marita, Rusch Sarah, DeVincenzo John, The Journal of Infectious Diseases . 2018,第5期

机译：口腔JNJ-53718678在健康成人志愿者抗病患者患有呼吸道合胞病毒的健康成人志愿者：安慰剂对照研究
2. A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein [J] . Antimicrobial agents and chemotherapy. . 2020,第2期

机译：随机，安慰剂对照，呼吸道合胞病毒的抗病毒功效，安全性和药代动力学的抗病毒功效，安全性和药代动力学，RV521，RSV-F蛋白的抑制剂
3. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study [J] . DeVincenzo John P., McClure Matthew W., Symons Julian A., The New England journal of medicine . 2015,第21期

机译：口服ALS-008176在呼吸道合胞病毒攻击研究中的活性
4. Human respiratory syncytial virus proteins suppress host cell innate antiviral responses via interferon-dependent and -independent pathways [C] . J. J. Gorman, N. Patel, A. Bukreyev Incorporating of the Australian Society for Biochemistry and Molecular Biology Combio . 2009

机译：人体呼吸合胞病毒蛋白通过干扰素依赖性和依赖性途径抑制宿主预防抗病毒反应
5. Targeted development of antivirals against influenza A and respiratory syncytial virus. [D] . Lupfer, Christopher. 2009

机译：靶向开发针对甲型流感和呼吸道合胞病毒的抗病毒药。
6. 1958. Antiviral Effects Pharmacokinetics (PK) and Safety of the Respiratory Syncytial Virus (RSV) Fusion Protein Inhibitor JNJ-53718678 (JNJ-8678) in RSV-infected Infants With Bronchiolitis in the Phase 1b Study 53718678RSV1005 [O] . Federico Martinon-Torres, Sarah Rusch, Dymphy Huntjens, -1

机译：1958年。呼吸道合胞病毒（RSV）融合蛋白抑制剂JNJ-53718678（JNJ-8678）的抗病毒作用药代动力学（PK）和安全性在1b期研究中被RSV感染的细支气管炎婴儿53718678RSV1005
7. Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study [O] . Marita Stevens, Sarah Rusch, John DeVincenzo, 2018

机译：口腔JNJ-53718678在健康成人志愿者抗病患者患有呼吸道合胞病毒的健康成人志愿者：安慰剂对照研究
8. Laboratory and Antigenic Studies of Respiratory Syncytial Virus;Evaluation of Respiratory Syncytial, Meningococcal,and Pneumococcal Polysaccharide Vaccines. [R] . forsyth,ben r. phillips,charles a. 1971

机译：呼吸道合胞病毒的实验室和抗原研究;呼吸道合胞体，脑膜炎球菌和肺炎球菌多糖疫苗的评估。

Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study

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