Live Attenuated Pru:Delta cdpk2 Strain of Toxoplasma gondii Protects Against Acute, Chronic, and Congenital Toxoplasmosis

Wang Jin-Lei; Li Ting-Ting; Elsheikha Hany M.; Chen Kai; Cong Wei; Yang Wen-Bin; Bai Meng-Jie; Huang Si-Yang; Zhu Xing-Quan

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Live Attenuated Pru:Delta cdpk2 Strain of Toxoplasma gondii Protects Against Acute, Chronic, and Congenital Toxoplasmosis

机译：Live Takenation PRU：Delta cdpk2弓形虫弓形虫可防止急性，慢性和先天性毒素

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Background. The threat of Toxoplasma gondii infection in immunocompromised individuals and pregnant women necessitates the development of a safe and effective vaccine. Here, we examined the immune protection conferred by a live attenuated strain of T. gondii.

机译：背景。免疫表现弓形虫感染弓形虫感染的威胁需要开发一个安全有效的疫苗。在这里，我们检查了通过T.Gondii的现场减毒菌株赋予的免疫保护。

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来源
《The Journal of Infectious Diseases》 |2018年第5期|共10页
作者
Wang Jin-Lei; Li Ting-Ting; Elsheikha Hany M.; Chen Kai; Cong Wei; Yang Wen-Bin; Bai Meng-Jie; Huang Si-Yang; Zhu Xing-Quan;
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作者单位

Chinese Acad Agr Sci Lanzhou Vet Res Inst Key Lab Vet Parasitol Gansu Prov State Key Lab Vet;

Chinese Acad Agr Sci Lanzhou Vet Res Inst Key Lab Vet Parasitol Gansu Prov State Key Lab Vet;

Univ Nottingham Sch Vet Med &

Sci Fac Med &

Hlth Sci Loughborough Leics England;

Chinese Acad Agr Sci Lanzhou Vet Res Inst Key Lab Vet Parasitol Gansu Prov State Key Lab Vet;

Shandong Univ Weihai Coll Marine Sci Weihai Shandong Peoples R China;

Chinese Acad Agr Sci Lanzhou Vet Res Inst Key Lab Vet Parasitol Gansu Prov State Key Lab Vet;

Chinese Acad Agr Sci Lanzhou Vet Res Inst Key Lab Vet Parasitol Gansu Prov State Key Lab Vet;

Chinese Acad Agr Sci Lanzhou Vet Res Inst Key Lab Vet Parasitol Gansu Prov State Key Lab Vet;

Chinese Acad Agr Sci Lanzhou Vet Res Inst Key Lab Vet Parasitol Gansu Prov State Key Lab Vet;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
Toxoplasma gondii; vaccination; Ca2+-dependent protein kinase 2; attenuated vaccine; protective immunity;

机译：弓形虫;疫苗接种;Ca2 +依赖性蛋白激酶2;减毒疫苗;保护性免疫;

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专利

1. Live Attenuated Pru:Delta cdpk2 Strain of Toxoplasma gondii Protects Against Acute, Chronic, and Congenital Toxoplasmosis [J] . Wang Jin-Lei, Li Ting-Ting, Elsheikha Hany M., The Journal of Infectious Diseases . 2018,第5期

机译：Live Takenation PRU：Delta cdpk2弓形虫弓形虫可防止急性，慢性和先天性毒素
2. Rat model of congenital toxoplasmosis: rate of transmission of three Toxoplasma gondii strains to fetuses and protective effect of a chronic infection. [J] . L Zenner, F Darcy, M F Cesbron-Delauw, Infection and immunity . 1993,第1期

机译：先天性弓形虫病的大鼠模型：三种弓形虫菌株向胎儿的传播率和慢性感染的保护作用。
3. Pathological changes in acute experimental toxoplasmosis with Toxoplasma gondii strains obtained from human cases of congenital disease [J] . Pinheiro Breno Veloso, Meirelles Noviello Maria de Lourdes, Cunha Mariana Maciel, Experimental parasitology . 2015,第Null期

机译：从人类先天性疾病病例获得的弓形虫弓形虫急性实验性弓形虫病的病理变化
4. Cloning and molecular analysis of Toxoplasma gondii Surface Antigen 2(SAG2)gene cloned from Toxoplasma gondii DNA isolated from Javanese acute toxoplasmosis [C] . W Monica, A A Prasetyo, S Haryati Annual Applied Science and Engineering Conference . 2019

机译：从爪哇急性毒素中分离出弓形虫DNA克隆弓形虫表面抗原2（SAG2）基因的克隆及分子分析
5. Attenuation of the acute immunosuppressive effects of delta-9-tetrahydrocannabinol follows chronic exposure [D] . Sheth, Christopher Michael 2009

机译：慢性暴露后delta-9-四氢大麻酚的急性免疫抑制作用减弱
6. RHΔgra17Δnpt1 Strain of Toxoplasma gondii Elicits Protective Immunity Against Acute Chronic and Congenital Toxoplasmosis in Mice [O] . Qin-Li Liang, Li-Xiu Sun, Hany M. Elsheikha, 2020

机译：弓形虫RHΔgra17Δnpt1菌株可引起针对急性慢性和先天性弓形虫病的小鼠保护性免疫
7. RHΔgra17Δnpt1 Strain of Toxoplasma gondii Elicits Protective Immunity Against Acute, Chronic and Congenital Toxoplasmosis in Mice [O] . Qin-Li Liang, Li-Xiu Sun, Hany M. Elsheikha, 2020

机译：rhΔGra17Δnpt1弓形虫的菌株对小鼠的急性，慢性和先天性毒素病引起的保护性免疫力

Live Attenuated Pru:Delta cdpk2 Strain of Toxoplasma gondii Protects Against Acute, Chronic, and Congenital Toxoplasmosis

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