A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study

Langley Joanne M.; MacDonald Lisa D.; Weir Genevieve M.; MacKinnon-Cameron Donna; Ye Lingyun; McNeil Shelly; Schepens Bert; Saelens Xavier; Stanford Marianne M.; Halperin Scott A.

首页> 外文期刊>The Journal of Infectious Diseases >A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study

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A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study

机译：基于用新型脂质的制剂呈现的小疏水蛋白外胚瘤的呼吸道同性恋病毒疫苗在成人中具有高度免疫原性和安全的：一项先进的研究

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Background. Respiratory syncytial virus infection can cause lower respiratory tract infection in older adults comparable to influenza, but no vaccines are available.

机译：背景。呼吸道合胞病毒感染可能导致与流感相当的老年人的呼吸道感染，但没有可用疫苗。

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来源
《The Journal of Infectious Diseases》 |2018年第3期|共10页
作者
Langley Joanne M.; MacDonald Lisa D.; Weir Genevieve M.; MacKinnon-Cameron Donna; Ye Lingyun; McNeil Shelly; Schepens Bert; Saelens Xavier; Stanford Marianne M.; Halperin Scott A.;
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作者单位

Dalhousie Univ Canadian Ctr Vaccinol IWK Hlth Ctr Halifax NS Canada;

Immunovaccine Halifax NS Canada;

Immunovaccine Halifax NS Canada;

Dalhousie Univ Canadian Ctr Vaccinol IWK Hlth Ctr Halifax NS Canada;

Dalhousie Univ Canadian Ctr Vaccinol IWK Hlth Ctr Halifax NS Canada;

Dalhousie Univ Canadian Ctr Vaccinol IWK Hlth Ctr Halifax NS Canada;

Univ Gent VIB Ctr Med Biotechnol Ghent Belgium;

Univ Gent VIB Ctr Med Biotechnol Ghent Belgium;

Dalhousie Univ Canadian Ctr Vaccinol IWK Hlth Ctr Halifax NS Canada;

Dalhousie Univ Canadian Ctr Vaccinol IWK Hlth Ctr Halifax NS Canada;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
Respiratory syncytial virus vaccines; aged; adult; immunization; vaccine immunogenicity; vaccines; inactivated vaccines; adjuvant;

机译：呼吸合胞病毒疫苗;年龄;成人;免疫;疫苗免疫原性;疫苗;灭活疫苗;佐剂;

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专利

1. A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study [J] . Langley Joanne M., MacDonald Lisa D., Weir Genevieve M., The Journal of Infectious Diseases . 2018,第3期

机译：基于用新型脂质的制剂呈现的小疏水蛋白外胚瘤的呼吸道同性恋病毒疫苗在成人中具有高度免疫原性和安全的：一项先进的研究
2. Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults [J] . Louis Fries, Vivek Shinde, Jeffrey J. Stoddard, Immunity Ageing . 2017,第1期

机译：老年人呼吸道合胞病毒融合蛋白（RSV F）纳米颗粒疫苗的免疫原性和安全性
3. A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model [J] . Hashem Anwar M., Algaissi Abdullah, Agrawal Anurodh Shankar, The Journal of Infectious Diseases . 2019,第10期

机译：基于高致呼吸综合征冠状病毒S1-CD40L融合蛋白在转基因人二肽基肽酶4小鼠模型中表达中东呼吸综合征冠状病毒S1-CD40L融合蛋白的高度免疫原性，保护性和安全的腺病毒的疫苗
4. Improved immunogenicity and plaque reduction from single dose combination respiratory syncytial virus (RSV) vaccine microparticle formulations [C] . K.Sokoll, P.Frank, S.Craig, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：单剂量联合呼吸道合胞病毒（RSV）疫苗微粒制剂可改善免疫原性并减少斑块
5. Studies on Nanoparticle Based Avian Influenza Vaccines to Present Immunogenic Epitopes of the Virus with Concentration on Ectodomain of Matrix 2 (M2e) Protein. [D] . Babapoor Dighaleh, Sankhiros. 2011

机译：基于纳米颗粒的禽流感疫苗的研究，以呈现病毒的免疫原性表位，并集中于基质2（M2e）蛋白的电子域。
6. A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study [O] . Joanne M Langley, Lisa D MacDonald, Genevieve M Weir, -1

机译：首次基于人类研究一种基于脂质的小分子疏水蛋白Ectodomain的呼吸道合胞病毒疫苗具有很高的免疫原性和安全性。
7. First-in-Human Randomized Study to Assess the Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus (RSV) Vaccine Based on Chimpanzee-Adenovirus-155 Viral Vector–Expressing RSV Fusion, Nucleocapsid, and Antitermination Viral Proteins in Healthy Adults [O] . Paola Cicconi, Claire Jones, Esha Sarkar, 2019

机译：首先是人类随机的研究，评估基于黑猩猩 - 腺病毒-155病毒载体的RSV融合，核衣壳和健康成人的硝基氨基葡萄病毒蛋白的安全性和免疫原性的疫苗的安全性和免疫原性
8. Laboratory and Antigenic Studies of Respiratory Syncytial Virus;Evaluation of Respiratory Syncytial, Meningococcal,and Pneumococcal Polysaccharide Vaccines. [R] . forsyth,ben r. phillips,charles a. 1971

机译：呼吸道合胞病毒的实验室和抗原研究;呼吸道合胞体，脑膜炎球菌和肺炎球菌多糖疫苗的评估。

A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study

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