Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model

Markus HKainulainen; Jessica RSpengler; Stephen RWelch; JoAnn DColeman-McCray; Jessica RHarmon; John DKlena; Stuart TNichol; César GAlbari?o; Christina FSpiropoulou

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Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model

机译：使用可扩展的复制子颗粒疫苗来保护豚鼠模型中的致死兰萨病毒感染

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Lassa fever is a viral zoonosis with a high annual case number in West Africa. A vaccine candidate comprising particles that replicate only in the first cells encountered conferred complete protection in a small-animal model.

机译：榻榻米是一种病毒性动物病，西非每年案件数量高。包含仅在遇到的第一细胞中遇到的小动物模型中的完全保护的颗粒候选疫苗候选候选物。

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来源
《The Journal of Infectious Diseases》 |2018年第12期|共10页
作者
Markus HKainulainen; Jessica RSpengler; Stephen RWelch; JoAnn DColeman-McCray; Jessica RHarmon; John DKlena; Stuart TNichol; César GAlbari?o; Christina FSpiropoulou;
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正文语种 eng
中图分类传染病;
关键词
Lassa; vaccine; virus replicon particle; VRP; single-cycle replication;

机译：榻榻米;疫苗;病毒复制子粒子;VRP;单周期复制;

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1. Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model [J] . Markus HKainulainen, Jessica RSpengler, Stephen RWelch, The Journal of Infectious Diseases . 2018,第12期

机译：使用可扩展的复制子颗粒疫苗来保护豚鼠模型中的致死兰萨病毒感染
2. The broad-spectrum antiviral favipiravir protects guinea pigs from lethal Lassa virus infection post-disease onset [J] . David Safronetz, Kyle Rosenke, Jonna B. Westover, Scientific reports. . 2015,第期

机译：广谱抗病毒性FaviPiravir保护来自疾病后致死的乳液病毒感染的豚鼠
3. A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses [J] . David Safronetz, Chad Mire, Kyle Rosenke, PLOS Neglected Tropical Diseases . 2015,第4期

机译：一种基于重组水泡性口腔炎病毒的拉沙热疫苗可以保护豚鼠和猕猴免受地理和遗传上不同的拉沙病毒的攻击
4. Effects of porcine reproductive and respiratory syndrome (PRRS) modified live virus vaccine on the host response of nursery pigs to co-infection with PRRS virus and porcine circovirus type 2b [C] . Megan C. Niederwerder, Nick V. L. Serao, Bhupinder Bawa, American Association of Swine Veterinarians Annual Meeting . 2015

机译：猪生殖和呼吸综合征（PRRS）改性活病毒疫苗对PRRS病毒和猪循环猪疗养猪宿主响应的影响
5. Production and evaluation of plant-derived vaccines for cytomegalovirus using guinea pig as an animal model. [D] . Rolwandson, Karen. 2009

机译：使用豚鼠作为动物模型生产和评估巨细胞病毒植物衍生疫苗。
6. Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model [O] . Markus H. Kainulainen, Jessica R. Spengler, Stephen R. Welch, -1

机译：使用可扩展的复制子颗粒疫苗来防止豚鼠模型中的致命拉萨病毒感染
7. A recombinant vesicular stomatitis-based Lassa fever vaccine elicits rapid and long-term protection from lethal Lassa virus infection in guinea pigs [O] . Derek R. Stein, Bryce M. Warner, Geoff Soule, 2019

机译：基于重组的脉络膜炎的兰萨发烧疫苗引发了豚鼠致死的兰萨群病毒感染的快速和长期保护
8. Monovalent Virus-Like Particle Vaccine Protects Guinea Pigs and Nonhuman Primates Against Infection with Multiple Marburg Viruses [R] . Swenson, D. L., Warfield, K. L., Larsen, T., 2008

机译：单价病毒样颗粒疫苗保护豚鼠和非人类灵长类动物免受多种马尔堡病毒的感染

Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model

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