Intramuscular Adeno-Associated Virus–Mediated Expression of Monoclonal Antibodies Provides 100% Protection Against Ebola Virus Infection in Mice

摘要

Adeno-associated virus–mediated expression of monoclonal antibodies confers 100% protection in mice when administered intramuscularly as early as 7 days prior to lethal mouse adapted Ebola virus challenge, offering an alternative strategy to traditional vaccination.