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Use of Viscosupplementation for Knee Osteoarthritis: An Update

机译:黏性补充剂治疗膝骨性关节炎的最新进展

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Because of the rising numbers of patients affected by osteoarthritis (OA), management decisions on how to minimize pain and improve function in OA patients are important, lntra-articular hyaluronic acid (IAHA) knee injections have become a common treatment in the management of knee OA. in an editorial appearing in the 2007 National Knowledge Week on Osteoarthritis: National Health Service Evidence, four questions were asked about the clinical use of IAHA treatment for OA: 1) Who is the ideal candidate for HA viscosupplementation? 2} Do the mechanical and biological effects differ in importance in different stages of the disease? 3) What is the ideal dose in early- and late-stage OA? 4) Can the biological effect be delivered by means other than injection? These key issues are addressed. On the basis of results from several systemic reviews and meta-analyses, we conclude that IAHA knee injections in patients with knee OA result in modest improvements when measured by validated outcomes.
机译:由于受骨关节炎(OA)影响的患者人数不断增加,因此如何减少OA患者的疼痛并改善其功能的管理决策非常重要,关节内透明质酸(IAHA)膝关节注射已成为治疗膝关节的常见治疗方法OA。在2007年全国骨关节炎知识周:国家卫生服务证据上发表的社论中,对IAHA治疗OA的临床使用提出了四个问题:1)谁是HA黏膜补充的理想人选? 2}在疾病的不同阶段,机械和生物学作用的重要性是否有所不同? 3)早期和晚期OA的理想剂量是多少? 4)是否可以通过注射以外的其他方式发挥生物学效应?这些关键问题已得到解决。根据一些系统评价和荟萃分析的结果,我们得出结论,以经过验证的结果衡量,IAHA膝关节OA患者的膝关节注射会导致适度的改善。

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