Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor

Koga Keisuke; Yamagata Ryo; Kohno Keita; Yamane Takuya; Shiratori-Hayashi Miho; Kohro Yuta; Tozaki-Saitoh Hidetoshi; Tsuda Makoto

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Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor

机译：慢性瘙痒小鼠模型中脊柱瘙痒透射神经元的敏化需要星形织造因子

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Background: Chronic itch is a highly debilitating symptom among patients with inflammatory skin diseases. Recent studies have revealed that gastrin-releasing peptide (GRP) and its receptor (gastrin-releasing peptide receptor [GRPR]) in the spinal dorsal horn (SDH) play a central role in itch transmission.

机译：背景：慢性瘙痒是炎症皮肤病患者的高度衰弱症状。最近的研究表明，在脊柱背角（SDH）中胃泌素释放肽（GRP）及其受体（胃泌素释放肽受体[GRPR]）在瘙痒透射中起着核心作用。

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来源
《The Journal of Allergy and Clinical Immunology》 |2020年第1期|共19页
作者
Koga Keisuke; Yamagata Ryo; Kohno Keita; Yamane Takuya; Shiratori-Hayashi Miho; Kohro Yuta; Tozaki-Saitoh Hidetoshi; Tsuda Makoto;
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作者单位

Kyushu Univ Grad Sch Pharmaceut Sci Dept Life Innovat Fukuoka Fukuoka Japan;

Kyushu Univ Grad Sch Pharmaceut Sci Dept Life Innovat Fukuoka Fukuoka Japan;

Kyushu Univ Grad Sch Pharmaceut Sci Dept Life Innovat Fukuoka Fukuoka Japan;

Kyushu Univ Grad Sch Pharmaceut Sci Dept Life Innovat Fukuoka Fukuoka Japan;

Kyushu Univ Grad Sch Pharmaceut Sci Dept Life Innovat Fukuoka Fukuoka Japan;

Kyushu Univ Grad Sch Pharmaceut Sci Dept Life Innovat Fukuoka Fukuoka Japan;

Kyushu Univ Grad Sch Pharmaceut Sci Dept Life Innovat Fukuoka Fukuoka Japan;

Kyushu Univ Grad Sch Pharmaceut Sci Dept Life Innovat Fukuoka Fukuoka Japan;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Contact dermatitis; chronic itch; gastrin-releasing peptide; gastrin-releasing peptide receptor; spinal dorsal horn neurons; astrocytes; lipocalin 2; CRISPR-Cas9; patch-clamp recordings;

机译：接触皮炎;慢性瘙痒;胃泌素释放肽;胃泌素释放肽受体;脊椎背角神经元;星形胶质细胞;脂素2;CRISPR-CAS9;贴片夹具;

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1. Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor [J] . Koga Keisuke, Yamagata Ryo, Kohno Keita, The Journal of Allergy and Clinical Immunology . 2020,第1期

机译：慢性瘙痒小鼠模型中脊柱瘙痒透射神经元的敏化需要星形织造因子
2. Altered expression of itch-related mediators in the lower cervical spinal cord in mouse models of two types of chronic itch [J] . Liu Bao-Wen, Li Zhi-Xiao, He Zhi-Gang, International journal of molecular medicine . 2019,第3期

机译：两种慢性瘙痒的小鼠模型中颞型脊髓中瘙痒相关介质的表达改变
3. Altered expression of itch?related mediators in the lower cervical spinal cord in mouse models of two types of chronic itch [J] . LiuBao?Wen, LiZhi?Xiao, HeZhi?Gang, International journal of molecular medicine . 2019,第3期

机译：改变了瘙痒的表达？在两种类型的慢性瘙痒的小鼠模型中的下颈脊髓相关介质
4. Astrocytic adaptation during cerebral angiogenesis follows the new vessel formation induced through chronic hypoxia in adult mouse cortex [C] . Kazuto Masamoto, Iwao Kanno Conference on Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics . 2014

机译：脑血管生成过程中的星形胶质细胞适应继之以成年小鼠皮层通过慢性缺氧诱导的新血管形成
5. Molecular Mediators of Acute and Chronic Itch in Mouse and Human Sensory Neurons [D] . Valtcheva, Manouela Vesselinova. 2018

机译：小鼠和人类感觉神经元急性和慢性瘙痒的分子介导物
6. Altered expression of itch-related mediators in the lower cervical spinal cord in mouse models of two types of chronic itch [O] . Bao-Wen Liu, Zhi-Xiao Li, Zhi-Gang He, -1

机译：两种慢性瘙痒小鼠模型中下颈脊髓瘙痒相关介质的表达变化
7. 312 Roles of brain-natriuretic peptide- and gastrin-releasing peptide-responsive neurons in spinal transmission of itchRoles of brain-natriuretic peptide- and gastrin-releasing peptide-responsive neurons in spinal transmission of itch [O] . F. Kusube, M. Tominaga, H. Kawasaki, 2016

机译：312脑 - 利钠肽和胃泌素 - 释放肽响应神经元在瘙痒的脑 - 钠肽和胃泌素释放肽响应神经元肌肌肌的脊髓旋转中

Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor

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