Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles

Ghebre Michael A.; Pang Pee Hwee; Diver Sarah; Desai Dhananjay; Bafadhel Mona; Haldar Koirobi; Kebadze Tatiana; Cohen Suzanne; Newbold Paul; Rapley Laura; Woods Joanne; Rugman Paul; Pavord Ian D.; Johnston Sebastian L.; Barer Michael; May Richard D.; Brightling Christopher E.

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Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles

机译：生物加热簇展示哮喘和慢性阻塞性肺病与明显的介质和微生物瘤型材重叠

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Background: Exacerbations of asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous. Objective: We sought to investigate the sputum cellular, mediator, and microbiome profiles of both asthma and COPD exacerbations.

机译：背景：哮喘和慢性阻塞性肺病（COPD）的恶化是非均相的。目的：我们试图探讨哮喘和COPD加剧的痰细胞，介体和微生物组谱。

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来源
《The Journal of Allergy and Clinical Immunology》 |2018年第6期|共22页
作者
Ghebre Michael A.; Pang Pee Hwee; Diver Sarah; Desai Dhananjay; Bafadhel Mona; Haldar Koirobi; Kebadze Tatiana; Cohen Suzanne; Newbold Paul; Rapley Laura; Woods Joanne; Rugman Paul; Pavord Ian D.; Johnston Sebastian L.; Barer Michael; May Richard D.; Brightling Christopher E.;
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作者单位

Univ Leicester Inst Lung Hlth NIHR Leicester Biomed Res Ctr Dept Infect Immun &

Inflammat;

Tan Tock Seng Hosp Dept Resp &

Crit Care Med Singapore Singapore;

Univ Leicester Inst Lung Hlth NIHR Leicester Biomed Res Ctr Dept Infect Immun &

Inflammat;

Univ Leicester Inst Lung Hlth NIHR Leicester Biomed Res Ctr Dept Infect Immun &

Inflammat;

Univ Oxford Resp Med Unit Nuffield Dept Med NDM Res Bldg Old Rd Campus Oxford England;

Univ Leicester Inst Lung Hlth NIHR Leicester Biomed Res Ctr Dept Infect Immun &

Inflammat;

Imperial Coll London Natl Heart &

Lung Inst London England;

MedImmune Cambridge England;

MedImmune Cambridge England;

MedImmune Cambridge England;

MedImmune Cambridge England;

MedImmune Cambridge England;

Univ Oxford Resp Med Unit Nuffield Dept Med NDM Res Bldg Old Rd Campus Oxford England;

Imperial Coll London Natl Heart &

Lung Inst London England;

Univ Leicester Inst Lung Hlth NIHR Leicester Biomed Res Ctr Dept Infect Immun &

Inflammat;

MedImmune Cambridge England;

Univ Leicester Inst Lung Hlth NIHR Leicester Biomed Res Ctr Dept Infect Immun &

Inflammat;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Asthma; chronic obstructive pulmonary disease; asthma and chronic obstructive pulmonary disease heterogeneity; inflammatory profiles; microbiome abundances; phylum and genus levels; factor and cluster analyses;

机译：哮喘;慢性阻塞性肺部疾病;哮喘和慢性阻塞性肺病异质性;炎症性曲线;微生物组大量;门和属级别;因子和聚类分析;

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专利

1. Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles [J] . Ghebre Michael A., Pang Pee Hwee, Diver Sarah, The Journal of Allergy and Clinical Immunology . 2018,第6期

机译：生物加热簇展示哮喘和慢性阻塞性肺病与明显的介质和微生物瘤型材重叠
2. Exacerbating Factors Induce Different Gene Expression Profiles in Peripheral Blood Mononuclear Cells from Asthmatics, Patients with Chronic Obstructive Pulmonary Disease and Healthy Subjects [J] . Pniewska Ewa, Sokolowska Milena, Kuprys-Lipinska Izabela, International archives of allergy and immunology . 2014,第4期

机译：加剧因素导致哮喘，慢性阻塞性肺疾病患者和健康受试者的外周血单个核细胞中不同的基因表达谱
3. A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype [J] . Hirai K., Shirai T., Suzuki M., Clinical and experimental allergy : . 2017,第11期

机译：鉴定和表征哮喘和慢性阻塞性肺病重叠表型的聚类方法
4. Risk factors and overlap between asthma and chronic obstructive pulmonary disease. [C] . ELENA DANTES, MAN MILENA ADINA, OANA CRISTINA ARGHIR, Recent advances in risk management, assessment and mitigation . 2010

机译：哮喘和慢性阻塞性肺疾病的危险因素和重叠。
5. Providing ethical care: Cardiopulmonary Resuscitation (CPR) for Chronic Obstructive Pulmonary Disease (COPD) Exacerbations in Patients with End Stage Lung Disease (ESLD). [D] . Young, Jeanne. 2010

机译：提供伦理护理：心肺复苏术（CPR）用于终末期肺病（ESLD）患者的慢性阻塞性肺疾病（COPD）加重。
6. Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles [O] . Michael A. Ghebre, Pee Hwee Pang, Sarah Diver, -1

机译：生物恶化集群显示哮喘和慢性阻塞性肺疾病重叠且介质和微生物组谱不同
7. Exacerbation Clusters Demonstrate Asthma and Chronic Obstructive Pulmonary Disease Overlap with Distinct Phenotypes [O] . K. Hyodo, H. Masuko, H. Oshima, 2020

机译：恶化群集展示哮喘和慢性阻塞性肺病重叠与明显的表型

Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles

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