Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p

摘要

Background: Mannose receptor (MRC1/CD206) has been suggested to mediate allergic sensitization and asthma to multiple glycoallergens, including cockroach allergens. Objective: We sought to determine the existence of a protective mechanism through which MRC1 limits allergic inflammation through its intronic miR-511-3p. Methods: We examined MRCl-mediated cockroach allergen uptake by lung macrophages and lung inflammation using C57BL/6 wild-type (WT) and Mrcl'*' mice. The role of miR-511-3p in macrophage polarization and cockroach