CDC42-related genes are upregulated in helper T cells from obese asthmatic children

摘要

Background: Pediatric obesity-related asthma is more severe and less responsive to medications than asthma in normal-weight children. Obese asthmatic children have nonatopic T-H(1)-polarized systemic inflammation that correlates with pulmonary function deficits, but the pathways underlying T-H(1)-polarized inflammation are not well understood.