Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells

Kim Do-Kyun; Beaven Michael A.; Metcalfe Dean D.; Olivera Ana

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Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells

机译：DJ-1与Lyn的相互作用对于IgE介导的人肥大细胞的刺激至关重要

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Background: DJ-1 is a redox-sensitive protein with multiple roles in cell homeostasis, levels of which are altered in patients with mast cell (MC)-related disorders. However, whether DJ-1 can regulate human MC function is unknown.

机译：背景：DJ-1是一种氧化还原敏感蛋白，具有细胞稳态中具有多种作用的蛋白质，其水平被肥大细胞（MC）相关疾病的患者改变。但是，DJ-1是否可以调节人MC功能是未知的。

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来源
《The Journal of Allergy and Clinical Immunology》 |2018年第1期|共20页
作者
Kim Do-Kyun; Beaven Michael A.; Metcalfe Dean D.; Olivera Ana;
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作者单位

NIAID Mast Cell Biol Sect Lab Allerg Dis Bethesda MD 20892 USA;

NHLBI Lab Mol Immunol NIH Bldg 10 Bethesda MD 20892 USA;

NIAID Mast Cell Biol Sect Lab Allerg Dis Bethesda MD 20892 USA;

NIAID Mast Cell Biol Sect Lab Allerg Dis Bethesda MD 20892 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Human mast cells; IgE receptor; Lyn activation; DJ-1; signaling; reactive oxygen species; spleen tyrosine kinase;

机译：人体肥大细胞;IgE受体;Lyn激活;DJ-1;信号;反应性氧气;脾酪氨酸激酶;

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专利

1. Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells [J] . Kim Do-Kyun, Beaven Michael A., Metcalfe Dean D., The Journal of Allergy and Clinical Immunology . 2018,第1期

机译：DJ-1与Lyn的相互作用对于IgE介导的人肥大细胞的刺激至关重要
2. Furaltadone suppresses IgE-mediated allergic response through the inhibition of Lyn/Syk pathway in mast cells [J] . Nam Seung Taek, Kim Hyun Woo, Kim Hyuk Soon, European Journal of Pharmacology: An International Journal . 2018,第期

机译：FurallyAdone通过抑制肥大细胞中的Lyn / Syk途径来抑制IgE介导的过敏反应
3. Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn [J] . Park Young Hwan, Kim Do-Kyun, Kim Hyun Woo, Biochemical Pharmacology . 2018,第期

机译：将抗癌药物候选剂AZD7762，抑制抗过敏药物抑制IgE介导的肥大细胞和通过抑制林和FYN的过敏反应
4. MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells [C] . Yukihiko Kitamura Symposium on Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease . 2005

机译：MITF和SGIGSF：一种基本的转录因子及其肥大细胞的发育和存活的目标粘附分子
5. Roles for the Src kinase Lyn in mast cell function and tumorigenesis. [D] . Hernandez-Hansen, Valerie. 2004

机译：Src激酶Lyn在肥大细胞功能和肿瘤发生中的作用。
6. Interaction of DJ-1 with Lyn is essential for IgE-mediatedstimulation of human mast cells [O] . Do-Kyun Kim, Michael A. Beaven, Dean D. Metcalfe, -1

机译：DJ-1与Lyn的相互作用对于IgE介导至关重要刺激人类肥大细胞
7. Balanced Interactions between Lyn, the p85α Regulatory Subunit of Class IA Phosphatidylinositol-3-Kinase, and SHIP Are Essential for Mast Cell Growth and Maturation▿ [O] . Ma, Peilin, Vemula, Sasidhar, Munugalavadla, Veerendra, 2011

机译：Lyn，IA类磷脂酰肌醇3-激酶的p85α调节亚基和SHIP之间的平衡相互作用对于肥大细胞的生长和成熟至关重要。

Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells

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