Catalyst-free, efficient and one pot protocol for synthesis of nitriles from aldehydes using glycerol as green solvent

摘要

We described herein the novel, efficient and one-pot catalyst free protocol for the synthesis of nitriles from aldehydes by using hydroxyl amine hydrochlorides in glycerol as a green solvent. This protocol was efficiently used for transformation of aromatic aldehydes bearing electron-withdrawing and electron -donating groups into a aryl nitriles in good to excellent yields. The methodology offers a very simple, efficient and environmentally benign procedure. (C) 2017 Elsevier Ltd. All rights reserved.