TBAI-mediated regioselective sulfenylation of indoles with sulfonyl chlorides in one pot

摘要

A versatile method for the synthesis of 3-sulfenylated indoles via TBAI promoted sulfenylation of indoles with sulfonyl chlorides in one pot has been presented. This system features highly regioselective, metal free, easy operation, and shows a broad functional group tolerance leading to excellent yields. And this reaction could be easily conducted in 10 mmol scale with high effectivity. A plausible mechanism is proposed. (C) 2017 Elsevier Ltd. All rights reserved.