A practical method, NaOCl-mediated, to prepare thiabendazoles via intramolecular amination reaction

摘要

Graphical abstract Display Omitted Highlights ? A practical method for the synthesize several thiabendazole derivatives. ? A metal-free protocol is documented. ? Good functional group tolerance. ? Easy access to structurally complex heterocycles. ? Fully characterized adducts are reported. Abstract A series of new chlorinated thiabendazoles (6a–m) have been synthesized from readily available anilines and 4-cyanothiazole in moderate to good yields. All synthesized compounds were fully characterized using 1H NMR, 13C NMR, IR, and mass spectrometry. Additionally, the structure of the compound (6f) was confirmed by single-crystal X-ray diffraction. In addition, synthesis of 2-substituted benzimidazoles and 2-phenyl benzothiazole was investigated using our optimized conditions and the outcome is presented herein. ]]>