Merging single-electron transfer and energy transfer processes of photocatalyst: An atom economical strategy for the synthesis of 1-trifluoroethylated isoquinolines from cis and trans vinyl isocyanides

摘要

Photoredox-catalyzed radical cascade trifluoroethylation-cyclization of cis and trans vinyl isocyanides with trifluoroethyl iodide involving an unusual single-electron transfer and energy transfer processes of photocatalyst provides an atom economical method for the synthesis of 1-trifluoroethylated isoquinolines. The process is notable for its operational simplicity and good functional group tolerance. (C) 2020 Elsevier Ltd. All rights reserved.