Rhodium-catalyzed regioselective C(sp(2))-H bond activation reactions o N-(hetero)aryl-7-azaindoles and cross-coupling with alpha-carbonyl sulfoxonium ylides

摘要

We described a protocol for rhodium-catalyzed C(sp(2))-H bond activation reactions of N-(hetero)aryl-7-azaindoles and cross-coupling with -carbonyl sulfoxonium ylides. In the C-H activation reaction, the 7-azaindole moiety acts as a directing group, which results in high regioselectivity. The protocol features excellent chemical yields and good functional group tolerance. (C) 2020 Published by Elsevier Ltd.