Beckmann rearrangement: Thiamine hydrochloride as a remarkable catalyst for one-pot synthesis of amides from ketones

摘要

Thiamine hydrochloride catalyzed synthesis of amides from ketones including 3-acetyl coumarin via Beckmann rearrangement has been reported. The reaction is believed to involve oxime formation, cleavage of C-C bond followed by C-N bond formation in one-pot. Thiamine hydrochloride is stable, cheap, easy to handle and environmentally friendly. (C) 2020 Elsevier Ltd. All rights reserved.