Synthesis of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives

Yaremchuk Iryna O.; Muzychka Lyubov V.; Smolii Oleg B.; Kucher Olexandr V.; Shishkina Svitlana V.

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Synthesis of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives

机译：新型1,2-二氢吡咯的合成[1,2-A]吡嗪-1（2H） - 酮衍生物

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The iodolactonization product obtained from methyl 7-allylpyrrolo[2,3-d]pyrimidine-6-carboxylate was used for the synthesis of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives, containing carboxamide- and methylamine-groups on the pyrrole ring of the heterocycle. (C) 2017 Elsevier Ltd. All rights reserved.

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来源
《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2018年第5期|共3页
作者
Yaremchuk Iryna O.; Muzychka Lyubov V.; Smolii Oleg B.; Kucher Olexandr V.; Shishkina Svitlana V.;
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作者单位

Natl Acad Sci Ukraine Inst Bioorgan Chem &

Petrochem 1 Murmanska Str UA-02094 Kiev Ukraine;

Natl Acad Sci Ukraine Inst Bioorgan Chem &

Petrochem 1 Murmanska Str UA-02094 Kiev Ukraine;

Natl Acad Sci Ukraine Inst Bioorgan Chem &

Petrochem 1 Murmanska Str UA-02094 Kiev Ukraine;

Natl Acad Sci Ukraine Inst Bioorgan Chem &

Petrochem 1 Murmanska Str UA-02094 Kiev Ukraine;

Natl Acad Sci Ukraine STC Inst Single Crystals 60 Nauky Ave UA-61001 Kharkov Ukraine;

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正文语种 eng
中图分类有机化学;
关键词
Pyrrolo2; 3-dpyrimidine; Pyrrolo1; 2-apyrazinone; Iodolactonization;

机译：Pyrrolo [2;3-D]嘧啶;Pyrrolo [1;2-a]吡嗪松;碘酰胺化;

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1. Synthesis of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives [J] . Yaremchuk Iryna O., Muzychka Lyubov V., Smolii Oleg B., Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2018,第5期

机译：新型1,2-二氢吡咯的合成[1,2-A]吡嗪-1（2H） - 酮衍生物
2. Identification and SAR of novel pyrrolo(1,2-a)pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). [J] . Pescatore G, Branca D, Fiore Bioorganic and Medicinal Chemistry Letters . 2010,第3期

机译：新型吡咯并（1,2-a）吡嗪-1（2H）-1衍生物作为聚（ADP-核糖）聚合酶-1（PARP-1）抑制剂的鉴定和SAR。
3. Selective synthesis of N-substituted pyrrolo[1,2-α]pyrazin-1(2H)-one derivatives via alkyne cyclization [J] . Yasin Cetinkaya, Metin Balci Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2014,第49期

机译：N-取代的吡咯并[1,2-α]吡嗪-1（2H）-一衍生物的炔烃环化选择性合成
4. Synthesis of 1,9-bis2'-(4-Cyclohexanyl-1,2-epoxide)ethyl-1,1,3,5,7,9,9-heptamethyl-3,5,7-tris(1H,1H,2H,2H-perfluoroalkyl)-pentasiloxanes and Their Thin Films [C] . Joseph M.Mabry, William P.Weber PMSE Symposia . 2002

机译：合成1,9-双2' - （4-环己基-1,2-环氧化）乙基 -1,1,3,5,7,9,9,9-己酰甲基-3,5,7-Tris（1H ，1H，2H，2H-全氟烷基） - 戊烷氧基及其薄膜
5. I. SYNTHETIC APPROACHES TO SUBSTITUTED 2-OXABICYCLO(3.2.1)OCTANE DERIVATIVES AND II. THE SYNTHESIS OF 1-SUBSTITUTED DERIVATIVES OF ANHYDRO (3-CHLOROACETYL-2-HYDROXYIMIDAZO(1,2-A)PYRIDINIUM HYDROXIDE). [D] . FRIEDMAN, ALAN E. 1973

机译：I.取代2-氧杂双环（3.2.1）正己烷衍生物的合成方法和II。合成1-取代的酸酐（3-氯乙酰基-2-羟基咪唑并（1,2-A）吡啶鎓氢氧化物）。
6. Development of Novel and Efficient Processes for the Synthesis of 5-Amino and 5-Iminoimidazo[1,2-a]imidazoles via Three-Component Reaction Catalyzed by Zirconium(IV) Chloride [O] . Mohsine Driowya, Régis Guillot, Pascal Bonnet, 1970

机译：氯化锆（IV）催化三组分反应合成5-氨基和5-氨基咪唑并[1,2-a]咪唑的新颖高效方法的进展
7. Imidazo(1,2-a)pyridines. I. Synthesis and Inotropic Activity of New 5-Imidazo(1,2-a)pyridinyl-2(1H)-pyridinone Derivatives. [O] . Motosuke YAMANAKA, Kazutoshi MIYAKE, Shinji SUDA, 1991

机译：咪唑（1,2-A）吡啶。 I.新的5-咪唑（1,2-A）吡啶基-2（1H） - 吡啶酮衍生物的合成和渗透活性。

Synthesis of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives

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