Copper-catalyzed direct cyanation of terminal alkynes with benzoyl cyanide

摘要

Copper-catalyzed direct cyanation of terminal alkynes is achieved using less toxic, stable and easy to handle benzoyl cyanide as a cyanide source and air as an oxidant. This protocol provides a good alternative to the preparation of 3-arylpropiolonitriles under mild condition. (C) 2018 Elsevier Ltd. All rights reserved.