Copper-catalyzed oxidative C-H bond functionalization of N-allylbenzamide for C-N and C-C bond formation

摘要

C-H bond functionalization for C-N and C-C bond formations via cross-dehydrogenative coupling (CDC) of N-allylbenzamides with indole as amine source has been developed under a copper-catalyzed condition. To the best of our knowledge, these are the first examples in which different classes of N-containing compounds were directly prepared from the readily available N-allylbenzamides using an inexpensive catalyst-oxidant (CuSO4/TBHP) system. Further, it was applied for the synthesis of a-substituted N-allylbenzamides by using Grignard reagent as nucleophiles. (C) 2019 Elsevier Ltd. All rights reserved.