Rhodamine based turn-on fluorescent sensor for Hg2+ and its application of microfluidic system and bioimaging

摘要

In this paper, a new rhodamine derivative bearing thiazole and thiocarbonyl moieties 1 was synthesized and its sensing behaviors toward various metal ions were investigated by fluorescence spectroscopies and UV/Vis. The ring-opening process of spirolactam enables the selective fluorescence enhancement and colorimetric change for Hg2+ in CH3CN-HEPES buffer (0.01 M, pH 7.4) (3:7, v/v). The selectivity and sensitivity of 1 towards Hg2+ lead to sensor 1 applied to microfluidic device and even used to functions Hg2+ sensing in Hela cells. (C) 2017 Elsevier Ltd. All rights reserved.