Ni(II)/tBu-SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines

摘要

An efficient Ni(ClO4)(2)center dot 6H(2)O/SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines is envisioned to afford excellent enantioselectivities (up to 99% ee) in high yields (up to 98%). This protocol offers new opportunities for the synthesis of chiral benzosultams containing a stereogenic tertiary carbon center. The highlights of this method include mild reaction conditions, the use of cheap metal catalyst and a wide substrate scope. (C) 2020 Elsevier Ltd. All rights reserved.