Efficient synthesis of alpha-substituted-alpha-arylmethyl phosphonates using trichloroacetimidate C-C coupling method

摘要

A simple convenient protocol for the synthesis of diethyl alpha,alpha-diaryl methylphosphonate derivatives 5a-f, 6b-f, 7a-f and 8a-f, diethyl alpha-alkenyl alpha-aryl methylphosphonates 9a-d and 10a-d and alpha-(oxoalkyl) alpha-aryl methylphosphonate 11a-d and 12a-d is described. Trichloroacetimidates 3a-d were treated with activated arenes, styrene, allyltrimethylsilane or silylenol ethers C-nucleophiles in the presence TMSOTf to afford the desired products in good yields and short reaction time. (C) 2018 Elsevier Ltd. All rights reserved.