An efficient route to quinoline-2-carboxylates via a rhodium-catalyzed oxidative [5+1] annulation of 2-vinylanilines with α-diazocarbonyl compounds

摘要

AbstractA novel rhodium-catalyzed oxidative [5?+?1] annulation of 2-vinylanilines with α-diazocarbonyl compounds for the construction of quinoline-2-carboxylate derivatives has been developed. A series of functional groups such as methyl, methoxy, fluoro, chloro, bromo, cyano, and even thienyl substituents were tolerated well. This methodology has the potential for use in the pharmaceutical industry.Graphical abstractDisplay Omitted]]>