BF3-promoted reactions between aryl aldehydes and 3-diazoindolin-2-imines: Access to 2-amino-3-arylindoles

摘要

An efficient and highly regioselective synthesis of 2-amino-3-arylindoles via the BF3-promoted reaction of 3-diazoindolin-2-imines with aryl aldehydes is described. This reaction could be carried out under mild reaction conditions with a broad scope of substrates. Moreover, the operation is of practical usage and could be scaled up. (C) 2019 Elsevier Ltd. All rights reserved.