A bioluminescent strategy for imaging palladium in living cells and animals with chemoselective probes based on luciferin-luciferase system

摘要

To develop a strategy for visualizing palladium species in the biological system, several turn-on bioluminescent probes were designed and synthesized by using a Pd-induced reductive reaction herein. Such probes exhibited high sensitivity (detection limit: 0.5 mu M) and excellent selectivity toward Pd2+ in vitro. In particular, probe 2 was identified as a viable molecule with the capability of visualizing the fluctuations of level and distribution of Pd2+ in living cells and animals, which provides a valuable tool for tracing Pd2+ in biological system.