Alterations in cytokine levels in cervical carcinoma patients through radiation therapy

摘要

Carcinoma cervix accounts for 86-90% of all genital cancers in Indian women. This is presented with prolonged infection and impairment of immune response even after completing the radiation therapy protocol. Increase in expression of IL-6 gene in invasive cervical carcinoma was observed against CIN and normal cervix. Evaluation of infiltrating lymphocytes TIL showed considerable CD3(+) and CD4(+) expression which predicted better prognosis and improved survival that was negated by increased IL-6.