Lack of solid tumour protection by Ocimum extract and its flavonoids orientin and vicenin

摘要

Ocimum leaf extract and its flavonoids orientin and vicenin protect normal tissues against radiation injury at nontoxic doses. For application in cancer patients, they should not protect tumours. Effect of extract (50 mg/kg) was studied on mouse fibrosarcoma. treated with radiation (10 Gy), cisplatinum (5 mg/kg) and withaferin A (40 mg/kg) by lung colony assay. Effect of orientin and vicenin (50 mug/kg) was studied on fibrosarcoma and B16F1 melanoma treated with radiation (30 Gy) or cyclophosphamide (300 mg/kg) by tumour regression and mouse survival. Neither the extract nor flavonoids gave any protection to tumours, suggesting that they are suitable for normal tissue protection in cancer therapy.