INSULIN STRUCTURE AND DIABETES TREATMENT

摘要

Insulin fibrils, formed by native and by monomeric molecules, have been prepared. When examined by electron microscopy they are indistinguishable. The packing of the monomeric insulin in the crystal lattice suggests how insulin fibres are constructed; the model explains the accelerated fibre formation by monomeric insulins and identifies mutations to probe the mechanism further. [References: 28]