Syntheses of Zn(II) and Cu(II) Schiff base complexes using N,O donor Schiff base ligand: Crystal structure, DNA binding, DNA cleavage, docking and DFT study

摘要

Two mononuclear Schiff base complexes, [Zn(L)(2)] (1) and [Cu(L)(2)] (2) are synthesized involving bidentate N,O-donor ligand viz. 2-((E)-(3-methoxypropylimino)methyl)-6-methoxyphenol. Different spectroscopic tools like FTIR, UV-Vis, H-1 NMR, C-13 NMR etc. have been deployed to characterize complexes 1 and 2. Complex 1 has been analyzed using single crystal X-ray diffraction analysis method. Complexes 1 and 2 show affinity towards A-T rich sequence of DNA which is further supported by molecular docking analysis. Interestingly, only complex 2 exhibits oxidative DNA cleavage activity in presence of H2O2 which is investigated by gel electrophoresis method. Complex I is found to be nontoxic whereas complex 2 is cytotoxic. (C) 2017 Elsevier Ltd. All rights reserved.