Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases

摘要

Proton magnetic resonance spectroscopic imaging (~1H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epliepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice ~1H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.