Prevention of radiation-induced damages by aqueous extract of Ganoderma lucidum occurring in southern parts of India.

摘要

Our previous studies have demonstrated that aqueous extract of G. lucidum occurring in South India possessed significant antioxidant activity. The present study was aimed at evaluating the radioprotective properties of the aqueous extract of this mushroom. Single-cell gel electrophoresis (comet assay), protection of radiation-induced plasmid pBR322 DNA strand breaks and inhibitions of lipid peroxidation (TBARS assay) were employed to determine the level of protection offered by the extract. The results indicate that aqueous extract of G. lucidum possessed significant radioprotective activity. The findings suggest the potential use of this mushroom extract for the prevention of radiationinduced cellular damages..