Application of Nanotechnology in Traditional Chinese Medicine

摘要

Nanomedicine is the medical application of nanotechnology and related research. Application of nanotechnology in the research of traditional Chinese medicine (TCM) may be an important direction towards its modernization. This paper reviews literatures on nano-TCM which were published in the past decade. In accordance with the different carriers, four types of nano-TCM, nanoliposome, solid lipid nanoparticle, nanocapsule and polymer micelle are analyzed. Most nano-TCMs are performed on nanoliposome for its easy preparation, convenience for application and multi-purpose administrations. Because of their characteristics of slow-release, targeting, toxicity etc., solid lipid nanoparticles are used mainly for the package of insoluble drugs as carriers for intravenous injection or local administration for the purpose of targeted or controlled release. Carrying drugs by natural or synthetic polymer material, nanocapsules can promote the drug through the blood-brain barrier and enhance drug's bioavailability. Polymer micelle, a new type of nanoparticle developed in recent years, can increase the solubility of hydrophobic drugs in body fluid and extend drug duration. Nanotechnology is conducive to the development of Chinese medicine in many ways, but there are many problems that need to be solved. Application of nanotechnology in the complex system of TCM is still in the initial stage, innovations of theory and technology are worth the wait to promote the nano-TCM into the practical stage.