Biosynthesis of Resorcylic Acid Lactone (5S)-5-Hydroxylasiodiplodin in Lasiodiplodia theobromae

摘要

An administration study of ~2H-labeled precursors showed that the 9-hydroxydecanoyl unit, the acyl intermediate of lasiodiplodin (1), was also the intermediate of (5S)-5-hydroxylasiodipIodin (2) in Lasiodiplodia theobromae. The incorporation of [O-methyl-~2H3]-lasio-diplodin (6) into 2 indicated that hydroxylation at C-5 occurred after cyclization.