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Determination of k(Q) factors for cylindrical and plane-parallel ionization chambers in a scanned carbon ion beam by means of cross calibration

机译:通过交叉校准测定扫描碳离子束中圆柱形和平面电离室的K(Q)因子

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摘要

The accuracy in the dosimetry of therapeutically used carbon ion beams is predominantly affected by the large uncertainty of the so-called k(Q) factor of the ionization chamber used for the measurements. Due to a lack of experimental data, the k(Q) factor of ionization chambers in carbon ion beams is still derived by calculation, and, for instance, a standard uncertainty of about 3% is given for k(Q) factors tabulated in the TRS-398 dosimetric protocol. Recently, k(Q) factors for two Farmer-type ionization chambers have been determined experimentally in the entrance channel of 429 MeV/u carbon ions, achieving about a threefold reduction of the uncertainty. To further improve the data basis on experimental k(Q) factors with low uncertainties, k(Q) factors for the same irradiation condition have now been determined for eight different cylindrical ionization chambers (NE2571, FC65-P, FC23-C, CC25, CC13, TM30010, TM30011, TM30012) and three different plane-parallel ionization chambers (PPC-40, PPC-05, TM34001) by means of a cross-calibration procedure. Generally, standard measurement uncertainties of 1.1% could be achieved. Deviations of less than 1.2% were found between the experimental and the tabulated k(Q) values. Moreover, the consideration of the experimental values with their smaller uncertainties in updated versions of the dosimetric protocols might enable a substantial reduction of the uncertainties in the dosimetry of carbon ion beams.
机译:治疗使用的碳离子束的剂量法中的准确度主要受到用于测量的电离室的所谓的K(Q)因子的大的不确定性。由于缺乏实验数据,碳离子束中的电离室的K(Q)因子仍然通过计算来导出,例如,给出了约3%的标准不确定度,以k(q)因子为单位TRS-398 Dosimetric协议。最近,k(q)两种农民式电离室的因素已经在429mev / u碳离子的入口通道中实验确定,实现了不确定度的三倍降低。为了进一步改善具有低不确定性的实验k(Q)因子的数据基础,现在已经确定了相同辐射条件的K(Q)因子已确定八个不同的圆柱电离室(NE2571,FC65-P,FC23-C,CC25, CC13,TM30010,TM30011,TM30012)和三种不同平面电离室(PPC-40,PPC-05,TM34001)通过交叉校准程序。通常,可以实现1.1%的标准测量不确定性。在实验和标记的K(Q)值之间发现小于1.2%的偏差。此外,在更新的剂量方案的更新版本中考虑实验值,其具有较小的不确定性,可以使碳离子束的剂量法中的不确定性大幅度降低。

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