Amine-Catalyzed Three-Component Cascade Reaction between Alcohols or Thiols, Activated Alkenes, and Enones: A Simple and Chemoselective Synthesis of Densely Functionalized Compounds

摘要

A highly chemoselective three-component cascade reaction among alcohols or thiols, electron-deficient alkenes, and alpha,beta-unsaturated ketones takes place under the catalysis of triethylamine, providing densely functionalized chain products in 44-99% yields. The transformation presumably proceeds through a sequential cascade of hetero-Michael/Michael reactions.